Rubella

Rubella and Congenital Rubella Syndrome

Generalities
Agent	Rubella virus, genus Rubullovirus, family Togaviridae
Incubation period	14-17 days (range 14-21 days)
Period of transmissibility	- 7 days before rash and 4 days after rash onset - From congenital rubella: infants shed the virus for several months after birth
Reservoir	Humans
Modes of transmission	- Person-to-person: direct contact with droplets - Infants with Congenital Rubella Syndrome shed large quantities of virus in their pharyngeal secretions and urine. - Materno-foetal transmission: 90% of infants born to women infected with rubella during the 1st trimester. The risk of transmission is 10-20% by the 16th week, and rare after the 20th week.
Clinical presentation	- Febril maculo-papular rash - Complications: thrombocytopenia (1/3000), post-infectious encephalitis (1/6000), rarely chronic arthritis - Congenital Rubella Syndrome: Congenital malformation as deafness, cataracts, microphtalmia, congenital glaucoma, pigmentary retinopathy, nystagmus, microcephaly, meningo-encephalitis, mental retardation, patent ductus arteious, atrial or ventricular septal defects, other congenital heart disease, purpura, hepatosplenomegaly, jaundice, radiolucent bone disease
Resources
Case definitions	- MOPH circular no 12 (2013): Acquired Rubella - MOPH circular no 45 (2007): Congenital Rubella Syndrome
Forms	- Rash reporting form - CRS reporting form - Rash investigation form - CRS investigation form
Data	- Rubella 2021 - Rubella 2020 - Rubella 2019 - Rubella 2018 - Rubella 2017 - Rubella 2016 - Rubella 2015

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ATC	Name	B/G	Ingredients	Dosage	Form	Price
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS	G	Potassium chloride - K+:1.5 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.75 mmol/l, Sodium acetate - Cl-:111.5 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
C08CA01	LOWRAC 5	G	Amlodipine (besylate) - 5mg	5mg	Capsule	362,837 L.L
C09DB06	LOSANET AM	G	Losartan potassium - 100mg, Amlodipine - 5mg		Tablet	1,044,358 L.L
H02AB07	PREDNISONE	G	Prednisone - 50mg	50mg	Tablet, scored	742,313 L.L
J01DD13	CEFODOX	G	Cefpodoxime (proxetil) - 50mg/5ml	50mg/5ml	Powder for suspension	604,729 L.L
J02AC02	FONGINOX	G	Itraconazole - 100mg	100mg	Capsule	778,149 L.L
L01BC06	CAPECITABINE SPC	G	Capecitabine - 500mg	500mg	Tablet, film coated	12,665,771 L.L
M02AA13	IBUSTICK	G	Ibuprofen - 50mg/g	50mg/g	Gel, roll on	857,372 L.L
N02BE01	UBSADOL BABY	G	Paracetamol - 120mg/5ml	120mg/5ml	Suspension	168,940 L.L
R03BA02	BUDESONIDE ARROW	G	Budesonide - 0.5mg/2ml	0.5mg/2ml	Inhalation suspension for nebuliser	1,342,499 L.L
S01AE07	FORTYMOX	G	Moxifloxacin (HCl) - 0.5%	0.5%	Drops solution	772,709 L.L
A03FA08	CINITREX	G	Cinitapride - 1mg	1mg	Tablet	636,981 L.L
A10BB12	GLYPRIDE	G	Glimepiride - 4mg	4mg	Tablet	657,139 L.L
B05BB02	5% DEXTROSE 0.9% SODIUM CHLORIDE INJECTION	G	Dextrose,H2O - 5g/100ml, Sodium chloride - 0.9g/100ml		Injectable solution	180,421 L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS2	G	Potassium chloride - K+:1.5 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.5 mmol/l, Sodium acetate - Cl-:111 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
C08CA01	LUSTRA	G	Amlodipine - 5mg	5mg	Tablet	485,127 L.L
C09DB07	CANDAM	G	Candesartan cilexetil - 8mg, Amlodipine - 5mg		Capsule, hard	923,220 L.L
D04AA32	DERMAMINE ITCH STOPPING	G	Diphenhydramine HCl - 1%, Zinc acetete - 0.1%		Cream	560,382 L.L
H02AB08	TRIACORT	G	Triamcinolone acetonide - 40mg/ml	40mg/ml	Injectable suspension	745,833 L.L
J02AC02	FONGINOX	G	Itraconazole - 100mg	100mg	Capsule	174,060 L.L
L01BC06	CAPEDA	G	Capecitabine - 500mg	500mg	Tablet, film coated	4,927,423 L.L
M02AA15	CLOFEN	G	Diclofenac sodium (diethylamine) - 10mg/g	1%	Creamagel	210,983 L.L
S01AE07	IMOX	G	Moxifloxacin (HCl) - 0.5%	0.5%	Drops	464,970 L.L
A10BB12	JOSWE GLEMAX 4	G	Glimepiride - 4mg	4mg	Caplet	235,172 L.L
B05BB02	5% DEXTROSE 0.9% SODIUM CHLORIDE INJECTION	G	Dextrose,H2O - 5g/100ml, Sodium chloride - 0.9g/100ml		Injectable solution	226,388 L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS3	G	Potassium chloride - K+:2.00 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.60 mmol/l, Sodium acetate - Cl-:112 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
C08CA01	NIPIDOL	G	Amlodipine - 5mg	5mg	Tablet	255,330 L.L
C09DB07	CORONOPINE	G	Candesartan cilexetil - 8mg, Amlodipine - 5mg		Capsule, hard	1,368,032 L.L
D04AA32	HISTERGAN	G	Diphenhydramine HCl - 2%	2%	Cream	546,944 L.L
G03AD01	EZ-ONE	G	Levonorgestrel - 1.5mg	1.5mg	Tablet	722,987 L.L

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