Meningitis

Generalities
Agent	There are several agents causing meningitis. 1) Main Bacteria: - Neisseria meningitidis (meningococcus): Gram negative diplococci. Main invasive serotypes are A, B, C, W135, X, and Y. - Haemophilus influenza: Gram negative cocco-bacilli. There are 6 serotypes from (a) to (f). The serotype (b) is responsible of invasive infection. - Streptococcus pneumonia (pneumococcus): Gram positive diplococci. There are more than 90 serotypes. - Leptospira: spirochetes, Leptospira interrogans (26 serogroups) - Listeria monocytogenes: Gram positive, rod-shapped - Other bacterial agents: Staphylococcus, enteric bacteria, group B streptococci, Mycobacterium tuberculosis… 2) Virus: - Mumps - Measles - West Nile virus: a Flavivirus - Enterovirus: including Coxsackieviruses A (2-4, 7, 9-10), Coxsackieviruses B (1-6), Echoviruses (2, 5-7, 9-11, 14, 18, 30), Enterovirus 71, Poliovirus (1-3) - Herpes Simplex virus (types 1 and 2): family Herpesviridae - Varicella-Zoster virus: Human (alpha) Herpesvirus 3 (varicella-zoster) from the group Herpesvirus - Adenovirus: Adenovirus, several types (1, 2, 3, 4, 5 and 7), genus Mastadenovirus, family Adenoviridae, - Lymphocytic choriomeningitis virus: an Arenavirus - Sandfly fever viruses: genus Phlebovirus, family Bunyaviridae. They include more than 60 antigenically distinct virus serotypes. Two main groups are identified: a) Sandfly fever group including the Naples serocomplex (Karimabad virus, Arabia virus, Massilia virus, Punique virus, Tehran virus, Toscana virus …) and Sicilian serocomplex; and b) Uukuniemi group -Other virus: arboviruses… 3) Parasites: - Candida albicans, cryptococcus…
Incubation period	varies with the agent
Period of transmissibility	varies with the agent
Reservoir	varies with the agent
Modes of transmission	varies with the agent
Clinical presentation	varies with the agent
Resources
Case definition	- MOPH circular no. 52 (2007): Meningitis - MOPH circular no. 63 (2007): Neisseria meningitidis - MOPH circular no. 54 (2007): Haemophilus influenzae b - MOPH circular no. 36 (2012): West Nile Virus
Forms	- Meningitis reporting form - Meningitis investigation form
Data	- Weekly report

ATC	Name	B/G	Ingredients	Dosage	Form	Price
L01EX01	SUNITINIB AQVIDA	G	Sunitinib maleate - 50mg	50mg	Capsule, hard	125,308,072 L.L
L01EX01	SUTENT	B	Sunitinib maleate - 25mg	25mg	Capsule	98,852,769 L.L
L01EX01	SOVIDEX	G	Sunitinib maleate - 25mg	25mg	Capsule	64,804,314 L.L
L01EX01	SUTENT	B	Sunitinib maleate - 12.5mg	12.5mg	Capsule	L.L
L01EX01	SUTENT	B	Sunitinib maleate - 12.5mg	12.5mg	Capsule	54,006,801 L.L
L01EX01	SOVIDEX	G	Sunitinib maleate - 12.5mg	12.5mg	Capsule	36,042,560 L.L
L01EX01	SUNITINIB AQVIDA	G	Sunitinib maleate - 12.5mg	12.5mg	Capsule, hard	38,073,237 L.L
N02CC01	IMIGRAN	B	Sumatriptan (succinate) - 50mg	50mg	Tablet, film coated	378,964 L.L
N02CC01	IMIGRAN	B	Sumatriptan (succinate) - 100mg	100mg	Tablet, film coated	616,824 L.L
N02CC01	SUMAREX	G	Sumatriptan (succinate) - 100mg	100mg	Tablet, film coated	1,088,512 L.L
B01AB11	VESSEL DUE F TAB.	B	Sulodexide - 250LRU	250LSU	Capsule, soft gelatin	2,792,505 L.L
B01AB11	ANGIOFLUX	G	Sulodexide - 250LRU	250LRU	Capsule, soft	2,026,514 L.L
R05X	ACTISOUFRE	B	Sulfure de Sodium - 13mg, Saccharomyces Cerevisiae - 500mg		Solution	740,457 L.L
D06BA02	CREM-O-SULFA	G	Sulfathiazole - 5%	5%	Cream	202,216 L.L
D06BA05	NEO SULFA	G	Sulfanilamide - 12g	12g	Powder	151,022 L.L
D06BA05	SULFANILAMIDE	G	Sulfanilamide - 12g	12g	Powder	151,022 L.L
S03AA30	SULFACHLOR	G	Sulfacetamide sodium - 110mg/ml, Chloramphenicol - 5mg/ml		Drops solution	202,216 L.L
V03AB35	PLIBADEX	G	Sugammadex - 500mg/5ml	500mg/5ml	Injectable solution	94,888,925 L.L
V03AB35	PLIBADEX	G	Sugammadex - 200mg/2ml	500mg/5ml	Injectable solution	46,089,190 L.L
V03AB35	BRIDION	B	Sugammadex - 100mg/ml	100mg/ml	Injectable solution	54,230,830 L.L
N01AH03	SUFENTANIL RENAUDIN	G	Sufentanil (citrate) - 5mcg/ml	10mcg/2ml	Injectable solution	755,239 L.L
N01AH03	SUFENTANIL RENAUDIN	G	Sufentanil (citrate) - 250mcg/5ml	250mcg/5ml	Injectable solution	3,524,899 L.L
A02BX02	SUCRATE GEL	G	Sucralfate - 1g	1g	Gel	636,981 L.L
J07CA	LANTIGEN B	B	Streptococcus pneumoniae type 3 (antigenic extracts) - 63.2A.U./ml, Streptococcus pyogenes group A (antigenic extracts) - 126.2A.U./ml, Branhamella catarrhalis (antigenic extracts) - 39.9A.U./ml, Staphylococcus aureus (antigenic extracts) - 79.6A.U./ml, Haemophilus influenzae type b (antigenic extracts) - 50.2A.U./ml, Klebsiella pneumoniae (antigenic extracts) - 39.8A.U./ml		Drops suspension	916,501 L.L
B05AA07	VOLUVEN	B	Starch poly(O-2-Hydroxyethyl) - 6%	6%	Injectable solution	987,724 L.L
C03DA01	ALDACTONE	B	Spironolactone - 25mg	25mg	Tablet	237,860 L.L
C03DA01	ALDACTONE	B	Spironolactone - 100mg	100mg	Tablet	458,250 L.L
J01FA02	ROVAMYCINE	B	Spiramycin - 3MIU	3MIU	Tablet, film coated	649,076 L.L
J01FA02	ROVAMYCINE	B	Spiramycin - 1.5MIU	1.5MIU	Tablet, film coated	256,674 L.L
B05BA02	SMOFLIPID	G	Soya oil - 6%, Olive oil - 5%, Fish oil - 3%, Medium chain triglycerides - 6%	20%	Injectable emulsion	1,424,473 L.L