Meningitis

Generalities
Agent	There are several agents causing meningitis. 1) Main Bacteria: - Neisseria meningitidis (meningococcus): Gram negative diplococci. Main invasive serotypes are A, B, C, W135, X, and Y. - Haemophilus influenza: Gram negative cocco-bacilli. There are 6 serotypes from (a) to (f). The serotype (b) is responsible of invasive infection. - Streptococcus pneumonia (pneumococcus): Gram positive diplococci. There are more than 90 serotypes. - Leptospira: spirochetes, Leptospira interrogans (26 serogroups) - Listeria monocytogenes: Gram positive, rod-shapped - Other bacterial agents: Staphylococcus, enteric bacteria, group B streptococci, Mycobacterium tuberculosis… 2) Virus: - Mumps - Measles - West Nile virus: a Flavivirus - Enterovirus: including Coxsackieviruses A (2-4, 7, 9-10), Coxsackieviruses B (1-6), Echoviruses (2, 5-7, 9-11, 14, 18, 30), Enterovirus 71, Poliovirus (1-3) - Herpes Simplex virus (types 1 and 2): family Herpesviridae - Varicella-Zoster virus: Human (alpha) Herpesvirus 3 (varicella-zoster) from the group Herpesvirus - Adenovirus: Adenovirus, several types (1, 2, 3, 4, 5 and 7), genus Mastadenovirus, family Adenoviridae, - Lymphocytic choriomeningitis virus: an Arenavirus - Sandfly fever viruses: genus Phlebovirus, family Bunyaviridae. They include more than 60 antigenically distinct virus serotypes. Two main groups are identified: a) Sandfly fever group including the Naples serocomplex (Karimabad virus, Arabia virus, Massilia virus, Punique virus, Tehran virus, Toscana virus …) and Sicilian serocomplex; and b) Uukuniemi group -Other virus: arboviruses… 3) Parasites: - Candida albicans, cryptococcus…
Incubation period	varies with the agent
Period of transmissibility	varies with the agent
Reservoir	varies with the agent
Modes of transmission	varies with the agent
Clinical presentation	varies with the agent
Resources
Case definition	- MOPH circular no. 52 (2007): Meningitis - MOPH circular no. 63 (2007): Neisseria meningitidis - MOPH circular no. 54 (2007): Haemophilus influenzae b - MOPH circular no. 36 (2012): West Nile Virus
Forms	- Meningitis reporting form - Meningitis investigation form
Data	- Weekly report

ATC	Name	B/G	Ingredients	Dosage	Form	Price
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS TYPE SG	G	Potassium chloride - 3.92g/l, Magnesium chloride, 6H2O - 5.32g/l, Calcium chloride, 2H2O - 8.99g/l, Sodium acetate, 3H2O - 166.7g/l, Sodium chloride - 214.76g/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS L	G	Potassium chloride - K+:1.5 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.75 mmol/l, Sodium acetate - Cl-:106.5 mmol/l, Sodium chloride - Na+:135 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LM	G	Potassium chloride - K+:2.00 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.75 mmol/l, Sodium acetate - Cl-:112 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS	G	Potassium chloride - K+:1.5 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.75 mmol/l, Sodium acetate - Cl-:111.5 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS2	G	Potassium chloride - K+:1.5 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.5 mmol/l, Sodium acetate - Cl-:111 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS LS3	G	Potassium chloride - K+:2.00 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.60 mmol/l, Sodium acetate - Cl-:112 mmol/l, Sodium chloride - Na+:140 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS R	G	Potassium chloride - K+:1.00 mmol/l, Magnesium chloride - Mg++:0.75 mmol/l, Calcium chloride - Ca++:1.40 mmol/l, Sodium acetate - Cl-:105.8 mmol/l, Sodium chloride - Na+:140.5 mmol/l		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTIONFOR HEMODIALYSIS TYPE A	G	Hemodialytics, concentrates -		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS TYPE B+	G	Hemodialytics, concentrates -		Injectable solution	L.L
B05ZA	CONCENTRATE SOLUTION FOR HEMODIALYSIS TYPE J	G	Hemodialytics, concentrates -		Injectable solution	L.L
C01BD01	CORDARONE	B	Amiodarone (HCl) - 200mg	200mg	Tablet, scored	349,399 L.L
C01BD01	CORDARONE	B	Amiodarone (HCl) - 150mg/3ml	150mg/3ml	Injectable concentrated solution	499,909 L.L
C01DX12	CORVASAL 2MG	B	Molsidomine - 2mg	2mg	Tablet, scored	398,033 L.L
C01DX12	CORVASAL 2MG	B	Molsidomine - 2mg	2mg	Tablet, scored	1,092,992 L.L
C01DX12	CORVASAL 4MG	B	Molsidomine - 4mg	4mg	Tablet	492,742 L.L
C01EB10	CARDESINE	G	Adenosine - 6mg/2ml	6mg/2ml	Injectable solution	563,070 L.L
C01EB15	CARMETADIN	G	Trimetazidine - 35mg	35mg	Tablet, film coated, modified release	631,606 L.L
C01EX	CARDIOVITEX	G	Coenzyme Q10 - 300mg, Magnesium oxide - 100mg		Tablet	2,822,069 L.L
C02AC05	CYNT	B	Moxonidine - 0.2mg	0.2mg	Tablet, film coated	901,735 L.L
C02AC05	CYNT	B	Moxonidine - 0.3mg	0.3mg	Tablet, film coated	1,218,134 L.L
C02AC05	CYNT	B	Moxonidine - 0.4mg	0.4mg	Tablet, film coated	1,218,134 L.L
C02CA04	CARDULAR	B	Doxazosin (mesylate) - 4mg	4mg	Tablet	755,239 L.L
C02CA04	CURCARD	G	Doxazosin (mesylate) - 4mg	4mg	Tablet	452,875 L.L
C05BA53	CONTRACTUBEX	B	Allantoin - 1g/100g, Cepae - 10g/100g, Heparin - 5000IU/100g		Gel	498,566 L.L
C05BA53	CONTRACTUBEX	B	Allantoin - 1g/100g, Cepae - 10g/100g, Heparin - 5,000IU/100g		Gel	1,183,925 L.L
C07AB07	CONCOR	B	Bisoprolol fumarate - 5mg	5mg	Tablet, film coated	837,017 L.L
C07AB07	CARDIOSAFE 5	G	Bisoprolol fumarate - 5mg	5mg	Tablet, coated	330,585 L.L
C07AB07	CONCOR	B	Bisoprolol fumarate - 10mg	10mg	Tablet, film coated	1,131,843 L.L
C07AB07	CARDIOSAFE 10	G	Bisoprolol fumarate - 10mg	10mg	Tablet, coated	610,104 L.L
C07AB07	CONCOR COR	B	Bisoprolol fumarate - 2.5mg	2.5mg	Tablet, film coated	470,283 L.L